Reductive ligation mediated one-step disulfide formation of S-nitrosothiols.
نویسندگان
چکیده
A one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the reaction of the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, which then undergo a fast intermolecular disulfide formation to form stable conjugates. This reaction can be used to design new biosensors of S-nitrosated proteins.
منابع مشابه
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ورودعنوان ژورنال:
- Organic letters
دوره 12 18 شماره
صفحات -
تاریخ انتشار 2010